The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.

The structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimethoprim has been refined at 2.0 A resolution. The analogous complex with NADPH and methotrexate has been refined at 2.5 A resolution. These structures reveal for the first time details of drug interactions with...

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Detalhes bibliográficos
Main Authors:	Stammers, D, Champness, J, Beddell, C, Dann, J, Eliopoulos, E, Geddes, A, Ogg, D, North, A
Formato:	Journal article
Idioma:	English
Publicado em:	1987

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