The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.

The structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimethoprim has been refined at 2.0 A resolution. The analogous complex with NADPH and methotrexate has been refined at 2.5 A resolution. These structures reveal for the first time details of drug interactions with...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Stammers, D, Champness, J, Beddell, C, Dann, J, Eliopoulos, E, Geddes, A, Ogg, D, North, A
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 1987