The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.

The structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimethoprim has been refined at 2.0 A resolution. The analogous complex with NADPH and methotrexate has been refined at 2.5 A resolution. These structures reveal for the first time details of drug interactions with...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Stammers, D, Champness, J, Beddell, C, Dann, J, Eliopoulos, E, Geddes, A, Ogg, D, North, A
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1987