The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.

The structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimethoprim has been refined at 2.0 A resolution. The analogous complex with NADPH and methotrexate has been refined at 2.5 A resolution. These structures reveal for the first time details of drug interactions with...

全面介紹

書目詳細資料
Main Authors: Stammers, D, Champness, J, Beddell, C, Dann, J, Eliopoulos, E, Geddes, A, Ogg, D, North, A
格式: Journal article
語言:English
出版: 1987