Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

The telomere repeat-binding factor 1 (TERF1, referred to hereafter as TRF1) is a component of mammalian telomeres whose role in telomere biology and disease has remained elusive. Here, we report on cells and mice conditionally deleted for TRF1. TRF1-deleted mouse embryonic fibroblasts (MEFs) show ra...

书目详细资料
Main Authors:	Martínez, P, Thanasoula, M, Muñoz, P, Liao, C, Tejera, A, McNees, C, Flores, J, Fernández-Capetillo, O, Tarsounas, M, Blasco, M
格式:	Journal article
语言:	English
出版:	2009

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