Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.

Regulation of survival, expansion, and differentiation of erythroid progenitors requires the well-controlled activity of signaling pathways induced by erythropoietin (Epo) and stem cell factor (SCF). In addition to qualitative regulation of signaling pathways, quantitative control may be essential t...

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Detalhes bibliográficos
Principais autores: Schmidt, U, van den Akker, E, Parren-van Amelsvoort, M, Litos, G, De Bruijn, M, Gutiérrez, L, Hendriks, R, Ellmeier, W, Löwenberg, B, Beug, H, von Lindern, M
Formato: Journal article
Idioma:English
Publicado em: 2004