Enantioselective total synthesis of (−)-Himalensine A via a palladium and 4-hydroxyproline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones
Herein, we describe the convergent enantioselective total synthesis of himalensine A in 18 steps, enabled by a highly enantio- and diastereoselective construction of the morphan core via a palladium/hydroxy proline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones. The reaction...
| Hlavní autoři: | , , , , , , , |
|---|---|
| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
American Chemical Society
2023
|