Enantioselective total synthesis of (−)-Himalensine A via a palladium and 4-hydroxyproline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones

Enantioselective total synthesis of (−)-Himalensine A via a palladium and 4-hydroxyproline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones

Herein, we describe the convergent enantioselective total synthesis of himalensine A in 18 steps, enabled by a highly enantio- and diastereoselective construction of the morphan core via a palladium/hydroxy proline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones. The reaction...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Kučera, R, Ellis, SR, Yamazaki, K, Hayward Cooke, J, Chekshin, N, Christensen, KE, Hamlin, TA, Dixon, DJ
Materialtyp: Journal article
Språk:English
Publicerad: American Chemical Society 2023

Liknande verk

Liknande verk