Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

The cellular genome is constantly subject to DNA damage caused by endogenous factors or exogenously by damaging agents such as ionizing radiation or various anticancer agents. The base excision repair (BER) enzyme, DNA polymerase β, and the polymerases involved in translesion synthesis (TLS) have be...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Nicolay, N, Helleday, T, Sharma, R
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2012

Antzeko izenburuak

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Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
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Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.
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