Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

The cellular genome is constantly subject to DNA damage caused by endogenous factors or exogenously by damaging agents such as ionizing radiation or various anticancer agents. The base excision repair (BER) enzyme, DNA polymerase β, and the polymerases involved in translesion synthesis (TLS) have be...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Nicolay, N, Helleday, T, Sharma, R
التنسيق:	Journal article
اللغة:	English
منشور في:	2012

مواد مشابهة

Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment
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منشور في: (2012)

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.
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منشور في: (2007)

Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.
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منشور في: (2018-02-01)

Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies
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SCREENING OF ONCOGENIC VARIANTS IN DNA POLYMERASES WITH TRANSLESION SYNTHESIS ACTIVITY IN MYELODYSPLASTIC NEOPLASM
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منشور في: (2023-10-01)

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A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
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Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage.
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منشور في: (2021-01-01)

Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis
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Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication
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منشور في: (2021)

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حسب: Bienko, M, وآخرون
منشور في: (2005)

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
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A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis.
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منشور في: (2015-09-01)

The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis
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منشور في: (2021-05-01)

Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1
حسب: Wiltrout, Mary Ellen, وآخرون
منشور في: (2015)

Biochemistry: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
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منشور في: (2005)

Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis
حسب: Kellinger, Matthew W., وآخرون
منشور في: (2014)

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.
حسب: Maga, G, وآخرون
منشور في: (2002)

Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts
حسب: Brittany N. Vandenberg, وآخرون
منشور في: (2023-05-01)

Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA.
حسب: Xing, G, وآخرون
منشور في: (2009)

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated
حسب: Olaug Elisabeth Torheim Bergum, وآخرون
منشور في: (2024-03-01)

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective
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منشور في: (2024-01-01)

Correction: The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
حسب: Carine Tellier-Lebegue, وآخرون
منشور في: (2018-02-01)

Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
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منشور في: (2017-12-01)

Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
حسب: Nicolay, N, وآخرون
منشور في: (2012)

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.
حسب: Blanca, G, وآخرون
منشور في: (2004)

Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine
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منشور في: (2010-01-01)

The role of DNA polymerase eta in determining cellular responses to chemo-radiation treatment
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منشور في: (2013)

Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ
حسب: Liang Song, وآخرون
منشور في: (2017-12-01)

Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis
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منشور في: (2022-08-01)

Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) κ, and Pol ζ
حسب: Wojtaszek, Jessica, وآخرون
منشور في: (2014)

De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase.
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DNA Polymerase e - More Than a Polymerase
حسب: Helmut Pospiech, وآخرون
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Phosphorylation Induced Conformational Transitions in DNA Polymerase β
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