Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

The cellular genome is constantly subject to DNA damage caused by endogenous factors or exogenously by damaging agents such as ionizing radiation or various anticancer agents. The base excision repair (BER) enzyme, DNA polymerase β, and the polymerases involved in translesion synthesis (TLS) have be...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Nicolay, N, Helleday, T, Sharma, R
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2012

Παρόμοια τεκμήρια

Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment
ανά: Nicolay, N, κ.ά.
Έκδοση: (2012)

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.
ανά: Bienko, M, κ.ά.
Έκδοση: (2010)

Translesion synthesis: Y-family polymerases and the polymerase switch.
ανά: Lehmann, A, κ.ά.
Έκδοση: (2007)

Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.
ανά: Parsons, J, κ.ά.
Έκδοση: (2013)

Translesion synthesis and error-prone polymerases.
ανά: Green, C, κ.ά.
Έκδοση: (2005)

Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis
ανά: L. Jay Stallons, κ.ά.
Έκδοση: (2010-01-01)

Role of Translesion Synthesis DNA Polymerases in DNA Replication in the Presence of a Weak DNA Polymerase δ in Saccharomyces cerevisiae
ανά: Likui Zhang, κ.ά.
Έκδοση: (2018-02-01)

Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies
ανά: Sushil Chandani, κ.ά.
Έκδοση: (2010-01-01)

SCREENING OF ONCOGENIC VARIANTS IN DNA POLYMERASES WITH TRANSLESION SYNTHESIS ACTIVITY IN MYELODYSPLASTIC NEOPLASM
ανά: RTG Oliveira, κ.ά.
Έκδοση: (2023-10-01)

Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery
ανά: Peter Tonzi, κ.ά.
Έκδοση: (2018-11-01)

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
ανά: Kinrin Yamanaka, κ.ά.
Έκδοση: (2012-01-01)

Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1
ανά: Tyler M. Weaver, κ.ά.
Έκδοση: (2022-05-01)

Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage.
ανά: Yuriko Inomata, κ.ά.
Έκδοση: (2021-01-01)

Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis
ανά: Kath, James E., κ.ά.
Έκδοση: (2014)

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication
ανά: Soriano, I, κ.ά.
Έκδοση: (2021)

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
ανά: Bienko, M, κ.ά.
Έκδοση: (2005)

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
ανά: Ignacio Soriano, κ.ά.
Έκδοση: (2021-07-01)

Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch
ανά: Radhika Malik, κ.ά.
Έκδοση: (2022-02-01)

A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis.
ανά: Michelle K Scotland, κ.ά.
Έκδοση: (2015-09-01)

The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis
ανά: Adhirath Sikand, κ.ά.
Έκδοση: (2021-05-01)

Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1
ανά: Wiltrout, Mary Ellen, κ.ά.
Έκδοση: (2015)

Biochemistry: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
ανά: Bienko, M, κ.ά.
Έκδοση: (2005)

Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis
ανά: Kellinger, Matthew W., κ.ά.
Έκδοση: (2014)

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.
ανά: Maga, G, κ.ά.
Έκδοση: (2002)

Translesion synthesis polymerases are dispensable for C. elegans reproduction but suppress genome scarring by polymerase theta-mediated end joining.
ανά: Ivo van Bostelen, κ.ά.
Έκδοση: (2020-04-01)

Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts
ανά: Brittany N. Vandenberg, κ.ά.
Έκδοση: (2023-05-01)

Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA.
ανά: Xing, G, κ.ά.
Έκδοση: (2009)

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
ανά: Carine Tellier-Lebegue, κ.ά.
Έκδοση: (2017-12-01)

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated
ανά: Olaug Elisabeth Torheim Bergum, κ.ά.
Έκδοση: (2024-03-01)

A Well-Conserved Archaeal B-Family Polymerase Functions as an Extender in Translesion Synthesis
ανά: Xu Feng, κ.ά.
Έκδοση: (2022-02-01)

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective
ανά: Anubrata Das, κ.ά.
Έκδοση: (2024-01-01)

Correction: The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
ανά: Carine Tellier-Lebegue, κ.ά.
Έκδοση: (2018-02-01)

Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
ανά: Elizabeth S. Thrall, κ.ά.
Έκδοση: (2017-12-01)

Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy.
ανά: Wendi Zhou, κ.ά.
Έκδοση: (2013-01-01)

Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change.
ανά: Deanna N Edwards, κ.ά.
Έκδοση: (2014-01-01)

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres
ανά: Laura Garcia-Exposito, κ.ά.
Έκδοση: (2016-11-01)

Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
ανά: Nicolay, N, κ.ά.
Έκδοση: (2012)

Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila.
ανά: Daniel P Kane, κ.ά.
Έκδοση: (2012-01-01)

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.
ανά: Blanca, G, κ.ά.
Έκδοση: (2004)

Translesion DNA synthesis in the context of cancer research
ανά: Knobel Philip A, κ.ά.
Έκδοση: (2011-11-01)