Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

The cellular genome is constantly subject to DNA damage caused by endogenous factors or exogenously by damaging agents such as ionizing radiation or various anticancer agents. The base excision repair (BER) enzyme, DNA polymerase β, and the polymerases involved in translesion synthesis (TLS) have be...

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Bibliographic Details
Main Authors:	Nicolay, N, Helleday, T, Sharma, R
Format:	Journal article
Language:	English
Published:	2012

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