A review of clinical models for the evaluation of human TB vaccines.
While much progress has been made in the fight against the scourge of tuberculosis (TB), we are still some way from reaching the ambitious targets of eliminating it as a global public health problem by the mid twenty-first century. A new and effective vaccine that protects against pulmonary TB dise...
| Egile Nagusiak: | , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
Taylor and Francis
2016
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| _version_ | 1826292494101381120 |
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| author | O'Shea, M McShane, H |
| author_facet | O'Shea, M McShane, H |
| author_sort | O'Shea, M |
| collection | OXFORD |
| description | While much progress has been made in the fight against the scourge of tuberculosis (TB), we are still some way from reaching the ambitious targets of eliminating it as a global public health problem by the mid twenty-first century. A new and effective vaccine that protects against pulmonary TB disease will be an essential element of any control strategy. Over a dozen vaccines are currently in development, but recent efficacy trial data from one of the most advanced candidates have been disappointing. Limitations of current preclinical animal models exist, together with a lack of a complete understanding of host immunity to TB or robust correlates of disease risk and protection. We aim to review these issues here and discuss possible solutions. Therefore, in the context of such obstacles, we discuss the lessons identified from recent efficacy trials, current concepts of biomarkers and correlates of protection, the potential of innovative clinical models such as human challenge and conducting trials in high incidence settings to evaluate TB vaccines in humans, and the use of systems vaccinology and novel technologies including transcriptomics and metabolomics, that may facilitate their utility. |
| first_indexed | 2024-03-07T03:15:33Z |
| format | Journal article |
| id | oxford-uuid:b5a753d5-32dd-438a-afcd-7bb3ac0e6ba1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:15:33Z |
| publishDate | 2016 |
| publisher | Taylor and Francis |
| record_format | dspace |
| spelling | oxford-uuid:b5a753d5-32dd-438a-afcd-7bb3ac0e6ba12022-03-27T04:35:12ZA review of clinical models for the evaluation of human TB vaccines.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b5a753d5-32dd-438a-afcd-7bb3ac0e6ba1EnglishSymplectic Elements at OxfordTaylor and Francis2016O'Shea, MMcShane, HWhile much progress has been made in the fight against the scourge of tuberculosis (TB), we are still some way from reaching the ambitious targets of eliminating it as a global public health problem by the mid twenty-first century. A new and effective vaccine that protects against pulmonary TB disease will be an essential element of any control strategy. Over a dozen vaccines are currently in development, but recent efficacy trial data from one of the most advanced candidates have been disappointing. Limitations of current preclinical animal models exist, together with a lack of a complete understanding of host immunity to TB or robust correlates of disease risk and protection. We aim to review these issues here and discuss possible solutions. Therefore, in the context of such obstacles, we discuss the lessons identified from recent efficacy trials, current concepts of biomarkers and correlates of protection, the potential of innovative clinical models such as human challenge and conducting trials in high incidence settings to evaluate TB vaccines in humans, and the use of systems vaccinology and novel technologies including transcriptomics and metabolomics, that may facilitate their utility. |
| spellingShingle | O'Shea, M McShane, H A review of clinical models for the evaluation of human TB vaccines. |
| title | A review of clinical models for the evaluation of human TB vaccines. |
| title_full | A review of clinical models for the evaluation of human TB vaccines. |
| title_fullStr | A review of clinical models for the evaluation of human TB vaccines. |
| title_full_unstemmed | A review of clinical models for the evaluation of human TB vaccines. |
| title_short | A review of clinical models for the evaluation of human TB vaccines. |
| title_sort | review of clinical models for the evaluation of human tb vaccines |
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