Calcium turns sinister in left-right asymmetry.
A major challenge in deciphering the development of left-right asymmetry in vertebrates is uncovering how subtle early differences between the left and right sides are translated into robust differences in gene expression. Recently, Raya and colleagues suggested that asymmetric localization of extra...
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797090239624249344 |
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| author | Shimeld, S |
| author_facet | Shimeld, S |
| author_sort | Shimeld, S |
| collection | OXFORD |
| description | A major challenge in deciphering the development of left-right asymmetry in vertebrates is uncovering how subtle early differences between the left and right sides are translated into robust differences in gene expression. Recently, Raya and colleagues suggested that asymmetric localization of extracellular calcium ions at the node could differentially modulate Notch signalling, resulting in asymmetric expression of the signalling molecule Nodal on the left side of the node. In this article, I examine the implications of this finding and explore their relevance to the evolution of asymmetry in vertebrates and invertebrates. |
| first_indexed | 2024-03-07T03:15:40Z |
| format | Journal article |
| id | oxford-uuid:b5ae709d-01b7-4df7-9514-5b69199538b9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:15:40Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:b5ae709d-01b7-4df7-9514-5b69199538b92022-03-27T04:35:29ZCalcium turns sinister in left-right asymmetry.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b5ae709d-01b7-4df7-9514-5b69199538b9EnglishSymplectic Elements at Oxford2004Shimeld, SA major challenge in deciphering the development of left-right asymmetry in vertebrates is uncovering how subtle early differences between the left and right sides are translated into robust differences in gene expression. Recently, Raya and colleagues suggested that asymmetric localization of extracellular calcium ions at the node could differentially modulate Notch signalling, resulting in asymmetric expression of the signalling molecule Nodal on the left side of the node. In this article, I examine the implications of this finding and explore their relevance to the evolution of asymmetry in vertebrates and invertebrates. |
| spellingShingle | Shimeld, S Calcium turns sinister in left-right asymmetry. |
| title | Calcium turns sinister in left-right asymmetry. |
| title_full | Calcium turns sinister in left-right asymmetry. |
| title_fullStr | Calcium turns sinister in left-right asymmetry. |
| title_full_unstemmed | Calcium turns sinister in left-right asymmetry. |
| title_short | Calcium turns sinister in left-right asymmetry. |
| title_sort | calcium turns sinister in left right asymmetry |
| work_keys_str_mv | AT shimelds calciumturnssinisterinleftrightasymmetry |