Plasticity in centromere organization and kinetochore composition: Lessons from diversity
Kinetochores are the macromolecular protein complexes that govern chromosome movement by binding spindle microtubules during mitosis and meiosis. Centromeres are the specific chromosomal regions that serve as the platform on which kinetochores assemble. Despite their essentiality for proper chromoso...
| Główni autorzy: | , |
|---|---|
| Format: | Journal article |
| Język: | English |
| Wydane: |
Elsevier
2022
|
| _version_ | 1826307472564944896 |
|---|---|
| author | Ishii, M Akiyoshi, B |
| author_facet | Ishii, M Akiyoshi, B |
| author_sort | Ishii, M |
| collection | OXFORD |
| description | Kinetochores are the macromolecular protein complexes that govern chromosome movement by binding spindle microtubules during mitosis and meiosis. Centromeres are the specific chromosomal regions that serve as the platform on which kinetochores assemble. Despite their essentiality for proper chromosome segregation, the size and organization of centromeres vary dramatically between species, while different compositions of kinetochores are found among eukaryotes. Here we discuss recent progress in understanding centromeres and kinetochores in non-traditional model eukaryotes. We specifically focus on select lineages (holocentric insects, early diverging fungi, and kinetoplastids) that lack CENP-A, a centromere-specific histone H3 variant that is critical for kinetochore specification and assembly in many eukaryotes. We also highlight some organisms that might have hitherto unknown types of kinetochore proteins. |
| first_indexed | 2024-03-07T07:03:38Z |
| format | Journal article |
| id | oxford-uuid:b5bed6b3-1e8d-4db5-9c58-e2330f8f7bc4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:03:38Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:b5bed6b3-1e8d-4db5-9c58-e2330f8f7bc42022-04-04T10:44:09ZPlasticity in centromere organization and kinetochore composition: Lessons from diversityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b5bed6b3-1e8d-4db5-9c58-e2330f8f7bc4EnglishSymplectic ElementsElsevier2022Ishii, MAkiyoshi, BKinetochores are the macromolecular protein complexes that govern chromosome movement by binding spindle microtubules during mitosis and meiosis. Centromeres are the specific chromosomal regions that serve as the platform on which kinetochores assemble. Despite their essentiality for proper chromosome segregation, the size and organization of centromeres vary dramatically between species, while different compositions of kinetochores are found among eukaryotes. Here we discuss recent progress in understanding centromeres and kinetochores in non-traditional model eukaryotes. We specifically focus on select lineages (holocentric insects, early diverging fungi, and kinetoplastids) that lack CENP-A, a centromere-specific histone H3 variant that is critical for kinetochore specification and assembly in many eukaryotes. We also highlight some organisms that might have hitherto unknown types of kinetochore proteins. |
| spellingShingle | Ishii, M Akiyoshi, B Plasticity in centromere organization and kinetochore composition: Lessons from diversity |
| title | Plasticity in centromere organization and kinetochore composition: Lessons from diversity |
| title_full | Plasticity in centromere organization and kinetochore composition: Lessons from diversity |
| title_fullStr | Plasticity in centromere organization and kinetochore composition: Lessons from diversity |
| title_full_unstemmed | Plasticity in centromere organization and kinetochore composition: Lessons from diversity |
| title_short | Plasticity in centromere organization and kinetochore composition: Lessons from diversity |
| title_sort | plasticity in centromere organization and kinetochore composition lessons from diversity |
| work_keys_str_mv | AT ishiim plasticityincentromereorganizationandkinetochorecompositionlessonsfromdiversity AT akiyoshib plasticityincentromereorganizationandkinetochorecompositionlessonsfromdiversity |