What are the genomic drivers of the rapid evolution of PRDM9?

What are the genomic drivers of the rapid evolution of PRDM9?

Mammalian Prdm9 has been proposed to be a key determinant of the positioning of chromosome double-strand breaks during meiosis, a contributor to speciation processes, and the most rapidly evolving gene in human, and other animal, genomes. Prdm9 genes often exhibit substantial variation in their numb...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Ponting, C
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2011

Eitemau Tebyg

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.
gan: Axelsson, E, et al.
Cyhoeddwyd: (2012)

PRDM9, a driver of the genetic map.
gan: Corinne Grey, et al.
Cyhoeddwyd: (2018-08-01)

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish
gan: Marie Raynaud, et al.
Cyhoeddwyd: (2025-01-01)

Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.
gan: Oliver, P, et al.
Cyhoeddwyd: (2009)

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome (Genome Research (2012) 22, (51-63))
gan: Axelsson, E, et al.
Cyhoeddwyd: (2012)

Extraordinary molecular evolution in the PRDM9 fertility gene.
gan: James H Thomas, et al.
Cyhoeddwyd: (2009-12-01)

Evolution of the recombination regulator PRDM9 in minke whales
gan: Elena Damm, et al.
Cyhoeddwyd: (2022-03-01)

PRDM9 marks the spot.
gan: McVean, G, et al.
Cyhoeddwyd: (2010)

Variability of PRDM9 in buffaloes
gan: Luca Godoi Rocha Santana, et al.
Cyhoeddwyd: (2025-01-01)

Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates
gan: Zachary Baker, et al.
Cyhoeddwyd: (2017-06-01)

Pinpointing the PRDM9-PRDM7 Gene Duplication Event During Primate Divergence
gan: Sacha Heerschop, et al.
Cyhoeddwyd: (2021-02-01)

Characterization of Prdm9 in equids and sterility in mules.
gan: Cynthia C Steiner, et al.
Cyhoeddwyd: (2013-01-01)

Discovery of a chemical probe for PRDM9
gan: Abdellah Allali-Hassani, et al.
Cyhoeddwyd: (2019-12-01)

High diversity at PRDM9 in chimpanzees and bonobos.
gan: Linn Fenna Groeneveld, et al.
Cyhoeddwyd: (2012-01-01)

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
gan: Altemose, N, et al.
Cyhoeddwyd: (2017)

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
gan: Nicolas Altemose, et al.
Cyhoeddwyd: (2017-10-01)

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
gan: Altemose, N, et al.
Cyhoeddwyd: (2017)

Cataloging Human PRDM9 Allelic Variation Using Long-Read Sequencing Reveals PRDM9 Population Specificity and Two Distinct Groupings of Related Alleles
gan: Benjamin Alleva, et al.
Cyhoeddwyd: (2021-11-01)

Novel genetic and molecular properties of meiotic recombination protein PRDM9
gan: Altemose, N
Cyhoeddwyd: (2015)

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots.
gan: Christopher L Baker, et al.
Cyhoeddwyd: (2015-09-01)

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL
gan: Brandi L. Carofino, et al.
Cyhoeddwyd: (2016-05-01)

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice
gan: Davies, B, et al.
Cyhoeddwyd: (2016)

Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation
gan: Erika Di Zazzo, et al.
Cyhoeddwyd: (2023-03-01)

PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
gan: Yukiko Imai, et al.
Cyhoeddwyd: (2020-10-01)

Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish
gan: Pedro Perdiguero, et al.
Cyhoeddwyd: (2020-10-01)

Zinc Finger Domain of the PRDM9 Gene on Chromosome 1 Exhibits High Diversity in Ruminants but Its Paralog PRDM7 Contains Multiple Disruptive Mutations.
gan: Sonika Ahlawat, et al.
Cyhoeddwyd: (2016-01-01)

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.
gan: Myers, S, et al.
Cyhoeddwyd: (2010)

Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.
gan: Petr Flachs, et al.
Cyhoeddwyd: (2012-01-01)

Altering the binding properties of PRDM9 partially restores fertility across the species boundary
gan: Davies, B, et al.
Cyhoeddwyd: (2021)

Emerging Roles of PRDM Factors in Stem Cells and Neuronal System: Cofactor Dependent Regulation of PRDM3/16 and FOG1/2 (Novel PRDM Factors)
gan: Paweł Leszczyński, et al.
Cyhoeddwyd: (2020-12-01)

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination
gan: Myers, Simon, et al.
Cyhoeddwyd: (2010)

Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice
gan: Sona Gregorova, et al.
Cyhoeddwyd: (2018-03-01)

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9
gan: Hong Wu, et al.
Cyhoeddwyd: (2013-10-01)

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
gan: Jacob Paiano, et al.
Cyhoeddwyd: (2020-02-01)

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex
gan: Ivanochko, D, et al.
Cyhoeddwyd: (2018)

What fraction of the human genome is functional?
gan: Ponting, C, et al.
Cyhoeddwyd: (2011)

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
gan: Cynthia Sandor, et al.
Cyhoeddwyd: (2012-01-01)

Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids.
gan: Petr Flachs, et al.
Cyhoeddwyd: (2014-01-01)

ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
gan: Wells, D, et al.
Cyhoeddwyd: (2020)

MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma
gan: Meng Li, et al.
Cyhoeddwyd: (2022-01-01)