What are the genomic drivers of the rapid evolution of PRDM9?

What are the genomic drivers of the rapid evolution of PRDM9?

Mammalian Prdm9 has been proposed to be a key determinant of the positioning of chromosome double-strand breaks during meiosis, a contributor to speciation processes, and the most rapidly evolving gene in human, and other animal, genomes. Prdm9 genes often exhibit substantial variation in their numb...

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Bibliografiske detaljer
Hovedforfatter:	Ponting, C
Format:	Journal article
Sprog:	English
Udgivet:	2011

Lignende værker

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.
af: Axelsson, E, et al.
Udgivet: (2012)

PRDM9, a driver of the genetic map.
af: Corinne Grey, et al.
Udgivet: (2018-08-01)

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish
af: Marie Raynaud, et al.
Udgivet: (2025-01-01)

Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.
af: Oliver, P, et al.
Udgivet: (2009)

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome (Genome Research (2012) 22, (51-63))
af: Axelsson, E, et al.
Udgivet: (2012)

Extraordinary molecular evolution in the PRDM9 fertility gene.
af: James H Thomas, et al.
Udgivet: (2009-12-01)

Evolution of the recombination regulator PRDM9 in minke whales
af: Elena Damm, et al.
Udgivet: (2022-03-01)

PRDM9 marks the spot.
af: McVean, G, et al.
Udgivet: (2010)

Variability of PRDM9 in buffaloes
af: Luca Godoi Rocha Santana, et al.
Udgivet: (2025-01-01)

Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates
af: Zachary Baker, et al.
Udgivet: (2017-06-01)

Pinpointing the PRDM9-PRDM7 Gene Duplication Event During Primate Divergence
af: Sacha Heerschop, et al.
Udgivet: (2021-02-01)

Characterization of Prdm9 in equids and sterility in mules.
af: Cynthia C Steiner, et al.
Udgivet: (2013-01-01)

Discovery of a chemical probe for PRDM9
af: Abdellah Allali-Hassani, et al.
Udgivet: (2019-12-01)

High diversity at PRDM9 in chimpanzees and bonobos.
af: Linn Fenna Groeneveld, et al.
Udgivet: (2012-01-01)

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
af: Altemose, N, et al.
Udgivet: (2017)

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
af: Nicolas Altemose, et al.
Udgivet: (2017-10-01)

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
af: Altemose, N, et al.
Udgivet: (2017)

Cataloging Human PRDM9 Allelic Variation Using Long-Read Sequencing Reveals PRDM9 Population Specificity and Two Distinct Groupings of Related Alleles
af: Benjamin Alleva, et al.
Udgivet: (2021-11-01)

Novel genetic and molecular properties of meiotic recombination protein PRDM9
af: Altemose, N
Udgivet: (2015)

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots.
af: Christopher L Baker, et al.
Udgivet: (2015-09-01)

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL
af: Brandi L. Carofino, et al.
Udgivet: (2016-05-01)

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice
af: Davies, B, et al.
Udgivet: (2016)

Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation
af: Erika Di Zazzo, et al.
Udgivet: (2023-03-01)

PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
af: Yukiko Imai, et al.
Udgivet: (2020-10-01)

Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish
af: Pedro Perdiguero, et al.
Udgivet: (2020-10-01)

Zinc Finger Domain of the PRDM9 Gene on Chromosome 1 Exhibits High Diversity in Ruminants but Its Paralog PRDM7 Contains Multiple Disruptive Mutations.
af: Sonika Ahlawat, et al.
Udgivet: (2016-01-01)

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.
af: Myers, S, et al.
Udgivet: (2010)

Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.
af: Petr Flachs, et al.
Udgivet: (2012-01-01)

Altering the binding properties of PRDM9 partially restores fertility across the species boundary
af: Davies, B, et al.
Udgivet: (2021)

Emerging Roles of PRDM Factors in Stem Cells and Neuronal System: Cofactor Dependent Regulation of PRDM3/16 and FOG1/2 (Novel PRDM Factors)
af: Paweł Leszczyński, et al.
Udgivet: (2020-12-01)

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination
af: Myers, Simon, et al.
Udgivet: (2010)

Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice
af: Sona Gregorova, et al.
Udgivet: (2018-03-01)

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9
af: Hong Wu, et al.
Udgivet: (2013-10-01)

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
af: Jacob Paiano, et al.
Udgivet: (2020-02-01)

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex
af: Ivanochko, D, et al.
Udgivet: (2018)

What fraction of the human genome is functional?
af: Ponting, C, et al.
Udgivet: (2011)

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
af: Cynthia Sandor, et al.
Udgivet: (2012-01-01)

Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids.
af: Petr Flachs, et al.
Udgivet: (2014-01-01)

ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
af: Wells, D, et al.
Udgivet: (2020)

MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma
af: Meng Li, et al.
Udgivet: (2022-01-01)