Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.
Treatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb) has been shown to suppress growth of a variety of different tumours in mice. These studies did not however determine whether or not anti-CD25 mAbs facilitate tumour rejection by depletion of regulatory T cells or by bindin...
| Autores principales: | , , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
2002
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| _version_ | 1826292528912007168 |
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| author | Jones, E Dahm-Vicker, M Simon, A Green, A Powrie, F Cerundolo, V Gallimore, A |
| author_facet | Jones, E Dahm-Vicker, M Simon, A Green, A Powrie, F Cerundolo, V Gallimore, A |
| author_sort | Jones, E |
| collection | OXFORD |
| description | Treatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb) has been shown to suppress growth of a variety of different tumours in mice. These studies did not however determine whether or not anti-CD25 mAbs facilitate tumour rejection by depletion of regulatory T cells or by binding to tumour-specific effector cells. Using a murine model of melanoma we have found that treatment of mice with anti-CD25 mAb facilitates long-term CD4+ T cell-mediated tumour immunity through depletion of CD25+ regulatory cells. We further show that the effector CD4+ T cells confer long-term tumour immunity even in the presence of CD25+ regulatory cells and do not require CD8+ T cells for tumour rejection. The inhibitory impact of anti-CD25 mAb treatment on tumour growth may be the result of depleting CD25+ regulatory cells that normally inhibit the generation of immune responses to self-antigens that are shared by the tumour. We have performed experiments to determine whether or not immune responses to melanocyte antigens are generated in anti-CD25 mAb-treated, melanoma-immune mice. The results of the experiments indicate that a T cell response to the melanocyte antigen tyrosinase accompanies suppression of tumour growth in mice lacking CD25+ regulatory cells. |
| first_indexed | 2024-03-07T03:16:06Z |
| format | Journal article |
| id | oxford-uuid:b5d54b8f-08e7-458f-a407-fee6a8f9e1fc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:16:06Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:b5d54b8f-08e7-458f-a407-fee6a8f9e1fc2022-03-27T04:36:37ZDepletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b5d54b8f-08e7-458f-a407-fee6a8f9e1fcEnglishSymplectic Elements at Oxford2002Jones, EDahm-Vicker, MSimon, AGreen, APowrie, FCerundolo, VGallimore, ATreatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb) has been shown to suppress growth of a variety of different tumours in mice. These studies did not however determine whether or not anti-CD25 mAbs facilitate tumour rejection by depletion of regulatory T cells or by binding to tumour-specific effector cells. Using a murine model of melanoma we have found that treatment of mice with anti-CD25 mAb facilitates long-term CD4+ T cell-mediated tumour immunity through depletion of CD25+ regulatory cells. We further show that the effector CD4+ T cells confer long-term tumour immunity even in the presence of CD25+ regulatory cells and do not require CD8+ T cells for tumour rejection. The inhibitory impact of anti-CD25 mAb treatment on tumour growth may be the result of depleting CD25+ regulatory cells that normally inhibit the generation of immune responses to self-antigens that are shared by the tumour. We have performed experiments to determine whether or not immune responses to melanocyte antigens are generated in anti-CD25 mAb-treated, melanoma-immune mice. The results of the experiments indicate that a T cell response to the melanocyte antigen tyrosinase accompanies suppression of tumour growth in mice lacking CD25+ regulatory cells. |
| spellingShingle | Jones, E Dahm-Vicker, M Simon, A Green, A Powrie, F Cerundolo, V Gallimore, A Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. |
| title | Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. |
| title_full | Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. |
| title_fullStr | Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. |
| title_full_unstemmed | Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. |
| title_short | Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. |
| title_sort | depletion of cd25 regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice |
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