Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.
Treatment with monoclonal antibodies (mAbs) specific for CD25 (anti-CD25 mAb) has been shown to suppress growth of a variety of different tumours in mice. These studies did not however determine whether or not anti-CD25 mAbs facilitate tumour rejection by depletion of regulatory T cells or by bindin...
Main Authors: | Jones, E, Dahm-Vicker, M, Simon, A, Green, A, Powrie, F, Cerundolo, V, Gallimore, A |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2002
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פריטים דומים
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Depletion of CD25+ regulatory cells results in suppression of melanomagrowth and induction of autoreactivity in mice
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Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens.
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The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice.
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Induction of inflammatory bowel disease in immunodeficient mice by depletion of regulatory T cells.
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Controlling Autoreactivity of CD4 T Cells by Local Tolerance Induction
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