Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

A defect in indoleamine 2,3-dioxygenase 1 (IDO1), which is responsible for immunoregulatory tryptophan catabolism, impairs development of immune tolerance to autoantigens in NOD mice, a model for human autoimmune type 1 diabetes (T1D). Whether IDO1 function is also defective in T1D is still unknown....

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Main Authors: Orabona, C, Mondanelli, G, Pallotta, MT, Carvalho, A, Albini, E, Fallarino, F, Vacca, C, Volpi, C, Belladonna, ML, Berioli, MG, Ceccarini, G, Esposito, SM, Scattoni, R, Verrotti, A, Ferretti, A, De Giorgi, G, Toni, S, Cappa, M, Matteoli, MC, Bianchi, R, Matino, D, Iacono, A, Puccetti, M, Cunha, C, Bicciato, S, Antognelli, C, Talesa, VN, Chatenoud, L, Fuchs, D, Pilotte, L, Van den Eynde, B, Lemos, MC, Romani, L, Puccetti, P, Grohmann, U
Format: Journal article
Language:English
Published: American Society for Clinical Investigation (ASCI) 2018

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