Integrating new memories into the hippocampal network activity space
By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2021
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| _version_ | 1797090276926291968 |
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| author | Gava, GP McHugh, SB Lefevre, L Lopes Dos Santos, V Trouche, S El-Gaby, M Schultz, SR Dupret, D |
| author_facet | Gava, GP McHugh, SB Lefevre, L Lopes Dos Santos, V Trouche, S El-Gaby, M Schultz, SR Dupret, D |
| author_sort | Gava, GP |
| collection | OXFORD |
| description | By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join co-activity motifs across behavioral events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories. |
| first_indexed | 2024-03-07T03:16:13Z |
| format | Journal article |
| id | oxford-uuid:b5e01cb9-4ba6-4fbf-a954-0d74bcb1cd6e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:16:13Z |
| publishDate | 2021 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:b5e01cb9-4ba6-4fbf-a954-0d74bcb1cd6e2022-03-27T04:36:51ZIntegrating new memories into the hippocampal network activity spaceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b5e01cb9-4ba6-4fbf-a954-0d74bcb1cd6eEnglishSymplectic ElementsNature Research2021Gava, GPMcHugh, SBLefevre, LLopes Dos Santos, VTrouche, SEl-Gaby, MSchultz, SRDupret, DBy investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join co-activity motifs across behavioral events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories. |
| spellingShingle | Gava, GP McHugh, SB Lefevre, L Lopes Dos Santos, V Trouche, S El-Gaby, M Schultz, SR Dupret, D Integrating new memories into the hippocampal network activity space |
| title | Integrating new memories into the hippocampal network activity space |
| title_full | Integrating new memories into the hippocampal network activity space |
| title_fullStr | Integrating new memories into the hippocampal network activity space |
| title_full_unstemmed | Integrating new memories into the hippocampal network activity space |
| title_short | Integrating new memories into the hippocampal network activity space |
| title_sort | integrating new memories into the hippocampal network activity space |
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