Novel microbubble preparation technologies
Gas microbubbles, stabilised by a surfactant or polymer coating, have become well established over the past 20-30 years as the most effective type of contrast agent available for ultrasound radiography. More recently, their potential for use in therapeutic applications including targeted drug delive...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826292537443221504 |
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| author | Stride, E Edirisinghe, M |
| author_facet | Stride, E Edirisinghe, M |
| author_sort | Stride, E |
| collection | OXFORD |
| description | Gas microbubbles, stabilised by a surfactant or polymer coating, have become well established over the past 20-30 years as the most effective type of contrast agent available for ultrasound radiography. More recently, their potential for use in therapeutic applications including targeted drug delivery, gene therapy, thrombolysis and focused ultrasound surgery has also been investigated. Developments in both diagnostic and therapeutic applications have greatly increased the need for more advanced preparation technologies which provide a high degree of control over microbubble size, composition, stability and uniformity. Conventional processing techniques such as sonication and high shear emulsification offer high yield and low cost production but poor control over microbubble size and uniformity. This is being addressed by the development of new technologies, such as membrane emulsification, inkjet printing, electrohydrodynamic atomisation and microfluidic processing which offer significant improvements in terms of control over microbubble characteristics. The aim of this paper is to review the range of techniques available for microbubble preparation and how these have evolved to keep pace with advances in clinical practice. © 2008 The Royal Society of Chemistry. |
| first_indexed | 2024-03-07T03:16:14Z |
| format | Journal article |
| id | oxford-uuid:b5e09387-904b-4313-a154-0c51b611cc6a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:16:14Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:b5e09387-904b-4313-a154-0c51b611cc6a2022-03-27T04:36:51ZNovel microbubble preparation technologiesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b5e09387-904b-4313-a154-0c51b611cc6aEnglishSymplectic Elements at Oxford2008Stride, EEdirisinghe, MGas microbubbles, stabilised by a surfactant or polymer coating, have become well established over the past 20-30 years as the most effective type of contrast agent available for ultrasound radiography. More recently, their potential for use in therapeutic applications including targeted drug delivery, gene therapy, thrombolysis and focused ultrasound surgery has also been investigated. Developments in both diagnostic and therapeutic applications have greatly increased the need for more advanced preparation technologies which provide a high degree of control over microbubble size, composition, stability and uniformity. Conventional processing techniques such as sonication and high shear emulsification offer high yield and low cost production but poor control over microbubble size and uniformity. This is being addressed by the development of new technologies, such as membrane emulsification, inkjet printing, electrohydrodynamic atomisation and microfluidic processing which offer significant improvements in terms of control over microbubble characteristics. The aim of this paper is to review the range of techniques available for microbubble preparation and how these have evolved to keep pace with advances in clinical practice. © 2008 The Royal Society of Chemistry. |
| spellingShingle | Stride, E Edirisinghe, M Novel microbubble preparation technologies |
| title | Novel microbubble preparation technologies |
| title_full | Novel microbubble preparation technologies |
| title_fullStr | Novel microbubble preparation technologies |
| title_full_unstemmed | Novel microbubble preparation technologies |
| title_short | Novel microbubble preparation technologies |
| title_sort | novel microbubble preparation technologies |
| work_keys_str_mv | AT stridee novelmicrobubblepreparationtechnologies AT edirisinghem novelmicrobubblepreparationtechnologies |