Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates
Methylation of lysine-4 of histone H3 (H3K4men) is an important regulatory factor in eukaryotic transcription. Removal of the transcriptionally activating H3K4 methylation is catalyzed by histone demethylases, including the Jumonji C (JmjC) KDM5 subfamily. The JmjC KDMs are Fe(II) and 2-oxoglutarate...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2017
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