OTUB1 is a key regulator of RIG-I-dependent immune signaling and is targeted for proteasomal degradation by influenza A NS1

OTUB1 is a key regulator of RIG-I-dependent immune signaling and is targeted for proteasomal degradation by influenza A NS1

Deubiquitylases (DUBs) regulate critical signaling pathways at the intersection of host immunity and viral pathogenesis. Although RIG-I activation is heavily dependent on ubiquitylation, systematic analyses of DUBs that regulate this pathway have not been performed. Using a ubiquitin C-terminal elec...

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Bibliographic Details
Main Authors: Jahan, AS, Biquand, E, Muñoz-Moreno, R, Le Quang, A, Mok, CK-P, Wong, HH, Teo, QW, Valkenburg, SA, Chin, AWH, Man Poon, LL, Te Velthuis, A, García-Sastre, A, Demeret, C, Sanyal, S
Format: Journal article
Language:English
Published: Elsevier 2020

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