Combining virotherapy and angiotherapy for the treatment of breast cancer
A breast cancer-selective oncolytic adenovirus was engineered to express antagonists of vascular endothelial growth factor (VEGF) and Notch signaling to combine direct anticancer activity with disruption of tumor-associated angiogenesis. Replication of the parental virus, AdEHE2F, is stimulated by e...
Main Authors: | Bazan-Peregrino, M, Sainson, R, Carlisle, R, Thoma, C, Waters, R, Arvanitis, C, Harris, A, Hernandez-Alcoceba, R, Seymour, L |
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Format: | Journal article |
Language: | English |
Published: |
2013
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