Global associations of key populations with HIV-1 recombinants: a systematic review, global survey, and individual participant data meta-analysis
Global HIV infections due to HIV-1 recombinants are increasing and impede prevention and treatment efforts. Key populations suffer most new HIV infections, but their role in the spread of HIV-1 recombinants is unknown. We conducted a global analysis of the associations between key populations and HI...
| Główni autorzy: | , , , , , |
|---|---|
| Kolejni autorzy: | |
| Format: | Journal article |
| Język: | English |
| Wydane: |
Frontiers Media
2023
|
| _version_ | 1826311553375272960 |
|---|---|
| author | Nchinda, N Elangovan, R Yun, J Dickson-Tetteh, L Kirtley, S Hemelaar, J |
| author2 | WHO-UNAIDS Network for HIV Isolation Characterisation |
| author_facet | WHO-UNAIDS Network for HIV Isolation Characterisation Nchinda, N Elangovan, R Yun, J Dickson-Tetteh, L Kirtley, S Hemelaar, J |
| author_sort | Nchinda, N |
| collection | OXFORD |
| description | Global HIV infections due to HIV-1 recombinants are increasing and impede prevention and treatment efforts. Key populations suffer most new HIV infections, but their role in the spread of HIV-1 recombinants is unknown. We conducted a global analysis of the associations between key populations and HIV-1 recombinants. We searched PubMed, EMBASE, CINAHL, and Global Health for HIV-1 subtyping studies published from 1/1/1990 to 31/12/2015. Unpublished data was collected through a global survey. We included studies with HIV-1 subtyping data of key populations collected during 1990–2015. Key populations assessed were heterosexual people (HET), men who have sex with men (MSM), people who inject drugs (PWID), vertical transmissions (VERT), commercial sex workers (CSW), and transfusion-associated infections (BLOOD). Logistic regression was used to determine associations of key populations with HIV-1 recombinants. Subgroup analyses were performed for circulating recombinant forms (CRFs), unique recombinant forms (URFs), regions, and time periods. Eight hundred and eighty five datasets including 77,284 participants from 83 countries were included. Globally, PWID were associated with the greatest odds of recombinants and CRFs [OR 2.6 (95% CI 2.46–2.74) and 2.99 (2.83–3.16)], compared to HET. CSW were associated with increased odds of recombinants and URFs [1.59 (1.44–1.75) and 3.61 (3.15–4.13)]. VERT and BLOOD were associated with decreased odds of recombinants [0.58 (0.54–0.63) and 0.43 (0.33–0.56)]. MSM were associated with increased odds of recombinants in 2010–2015 [1.43 (1.35–1.51)]. Subgroup analyses supported our main findings. As PWID, CSW, and MSM are associated with HIV-1 recombinants, increased preventative measures and HIV-1 molecular surveillance are crucial within these key population. |
| first_indexed | 2024-03-07T08:11:31Z |
| format | Journal article |
| id | oxford-uuid:b60b6d39-b051-4d6c-ad8b-bde52ec87b92 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:11:31Z |
| publishDate | 2023 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:b60b6d39-b051-4d6c-ad8b-bde52ec87b922023-11-28T09:12:17ZGlobal associations of key populations with HIV-1 recombinants: a systematic review, global survey, and individual participant data meta-analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b60b6d39-b051-4d6c-ad8b-bde52ec87b92EnglishSymplectic ElementsFrontiers Media2023Nchinda, NElangovan, RYun, JDickson-Tetteh, LKirtley, SHemelaar, JWHO-UNAIDS Network for HIV Isolation CharacterisationGlobal HIV infections due to HIV-1 recombinants are increasing and impede prevention and treatment efforts. Key populations suffer most new HIV infections, but their role in the spread of HIV-1 recombinants is unknown. We conducted a global analysis of the associations between key populations and HIV-1 recombinants. We searched PubMed, EMBASE, CINAHL, and Global Health for HIV-1 subtyping studies published from 1/1/1990 to 31/12/2015. Unpublished data was collected through a global survey. We included studies with HIV-1 subtyping data of key populations collected during 1990–2015. Key populations assessed were heterosexual people (HET), men who have sex with men (MSM), people who inject drugs (PWID), vertical transmissions (VERT), commercial sex workers (CSW), and transfusion-associated infections (BLOOD). Logistic regression was used to determine associations of key populations with HIV-1 recombinants. Subgroup analyses were performed for circulating recombinant forms (CRFs), unique recombinant forms (URFs), regions, and time periods. Eight hundred and eighty five datasets including 77,284 participants from 83 countries were included. Globally, PWID were associated with the greatest odds of recombinants and CRFs [OR 2.6 (95% CI 2.46–2.74) and 2.99 (2.83–3.16)], compared to HET. CSW were associated with increased odds of recombinants and URFs [1.59 (1.44–1.75) and 3.61 (3.15–4.13)]. VERT and BLOOD were associated with decreased odds of recombinants [0.58 (0.54–0.63) and 0.43 (0.33–0.56)]. MSM were associated with increased odds of recombinants in 2010–2015 [1.43 (1.35–1.51)]. Subgroup analyses supported our main findings. As PWID, CSW, and MSM are associated with HIV-1 recombinants, increased preventative measures and HIV-1 molecular surveillance are crucial within these key population. |
| spellingShingle | Nchinda, N Elangovan, R Yun, J Dickson-Tetteh, L Kirtley, S Hemelaar, J Global associations of key populations with HIV-1 recombinants: a systematic review, global survey, and individual participant data meta-analysis |
| title | Global associations of key populations with HIV-1 recombinants: a systematic review, global survey, and individual participant data meta-analysis |
| title_full | Global associations of key populations with HIV-1 recombinants: a systematic review, global survey, and individual participant data meta-analysis |
| title_fullStr | Global associations of key populations with HIV-1 recombinants: a systematic review, global survey, and individual participant data meta-analysis |
| title_full_unstemmed | Global associations of key populations with HIV-1 recombinants: a systematic review, global survey, and individual participant data meta-analysis |
| title_short | Global associations of key populations with HIV-1 recombinants: a systematic review, global survey, and individual participant data meta-analysis |
| title_sort | global associations of key populations with hiv 1 recombinants a systematic review global survey and individual participant data meta analysis |
| work_keys_str_mv | AT nchindan globalassociationsofkeypopulationswithhiv1recombinantsasystematicreviewglobalsurveyandindividualparticipantdatametaanalysis AT elangovanr globalassociationsofkeypopulationswithhiv1recombinantsasystematicreviewglobalsurveyandindividualparticipantdatametaanalysis AT yunj globalassociationsofkeypopulationswithhiv1recombinantsasystematicreviewglobalsurveyandindividualparticipantdatametaanalysis AT dicksontettehl globalassociationsofkeypopulationswithhiv1recombinantsasystematicreviewglobalsurveyandindividualparticipantdatametaanalysis AT kirtleys globalassociationsofkeypopulationswithhiv1recombinantsasystematicreviewglobalsurveyandindividualparticipantdatametaanalysis AT hemelaarj globalassociationsofkeypopulationswithhiv1recombinantsasystematicreviewglobalsurveyandindividualparticipantdatametaanalysis |