A "no-hybrids" screen for functional antagonizers of human p53 transactivator function: dominant negativity in fission yeast.

We have developed a functional "no-hybrids" screen in the fission yeast Schizosaccharomyces pombe based on the transcription transactivator activity of human p53. The screen can be used to identify antagonizers and modulators of p53 activity. Expression of functional full-length human p53...

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Bibliographic Details
Main Authors: Waddell, S, Jenkins, JR, Proikas-Cezanne, T
Format: Journal article
Language:English
Published: 2001