On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to i...

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Bibliographic Details
Main Authors: Edgar, RCS, Malcolm, TR, Siddiqui, G, Giannangelo, C, Counihan, NA, Challis, M, Duffy, S, Chowdhury, M, Marfurt, J, Dans, M, Wirjanata, G, Noviyanti, R, Daware, K, Suraweera, CD, Price, RN, Wittlin, S, Avery, VM, Drinkwater, N, Charman, SA, Creek, DJ, de Koning-Ward, TF, Scammells, PJ, McGowan, S
Format: Journal article
Language:English
Published: American Society for Microbiology 2024

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