Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.

Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.

The age of onset of Huntington's disease (HD) is inversely correlated with the CAG length in the HD gene. The CAG repeat length accounts for 70% of the variability in HD age of onset. However, 90% of individuals worldwide with expanded alleles possess between 40 and 50 CAG repeat lengths in the...

書目詳細資料
Main Authors:	Gayán, J, Brocklebank, D, Andresen, J, Alkorta-Aranburu, G, Zameel Cader, M, Roberts, SA, Cherny, S, Wexler, N, Cardon, L, Housman, D
格式:	Journal article
語言:	English
出版:	2008

相似書籍

Genomewide linkage analysis of age of onset of Huntington's disease
由: Gayan, J, et al.
出版: (2007)

Genomewide linkage analysis for loci affecting electrocardiographic LV mass
由: Padmanabhan, S, et al.
出版: (2006)

Evaluating the results of genomewide linkage scans of complex traits by locus counting.
由: Wiltshire, S, et al.
出版: (2002)

High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci.
由: Steven E Boyden, et al.
出版: (2010-08-01)

Multiple locus linkage analysis of genomewide expression in yeast.
出版: (2005-08-01)

Multiple locus linkage analysis of genomewide expression in yeast.
由: John D Storey, et al.
出版: (2005-08-01)

A genomewide scan for loci involved in attention-deficit/hyperactivity disorder.
由: Fisher, S, et al.
出版: (2002)

A genomewide linkage screen for relative hand skill in sibling pairs.
由: Francks, C, et al.
出版: (2002)

Replication of linkage of familial hypobetalipoproteinemia to chromosome 3p in six kindreds
由: Rosalind J. Neuman, et al.
出版: (2002-03-01)

Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height.
由: Hirschhorn, J, et al.
出版: (2001)

A genomewide scan identifies two novel loci involved in specific language impairment.
由: Consortium, S
出版: (2002)

KINDRED IN DEATH /
由: Robb, J. D., 1950-, author 233833
出版: (2009)

Bivariate linkage scan for reading disability and attention-deficit/hyperactivity disorder localizes pleiotropic loci.
由: Gayán, J, et al.
出版: (2005)

Refining the diagnosis of Huntington Disease: The PREDICT-HD study
由: Kevin M Biglan, et al.
出版: (2013-04-01)

Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study.
由: Lindgren, C, et al.
出版: (2002)

Meta-analysis in ankylosing spondylitis (AS) - Genomewide linkage map including 589 affected sibling pairs.
由: Carter, K, et al.
出版: (2005)

Meta-analysis in ankylosing spondylitis (AS) - Genomewide linkage map including 589 affected sibling pairs
由: Carter, K, et al.
出版: (2005)

LINKAGE STUDIES IN A KINDRED WITH AUTOSOMAL-DOMINANT SPONDYLOEPIMETAPHYSEAL DYSPLASIA (SEMD) INDICATE GENETIC-HETEROGENEITY
由: Gertner, J, et al.
出版: (1995)

Quantifying the effects of imputation on the power, coverage and cost-efficiency of genomewide SNP platforms
由: Anderson, C, et al.
出版: (2008)

Genomewide association study of leprosy.
由: Wong, S, et al.
出版: (2010)

Genomewide study of multiple sclerosis.
由: Ramagopalan, S, et al.
出版: (2007)

Evidence of linkage to chromosome 9q22.33 in colorectal cancer kindreds from the United Kingdom.
由: Kemp, Z, et al.
出版: (2006)

Linkage studies of a Missouri kindred with autosomal dominant spondyloepimetaphyseal dysplasia (SEMD) indicate genetic heterogeneity.
由: Gertner, J, et al.
出版: (1997)

B27 Disruption of melatonin circadian rhythmicity in Huntington's disease (HD)
由: Kalliolia, E, et al.
出版: (2012)

Prevalence of neurocognitive disorder in Huntington’s disease using the Enroll-HD dataset
由: Luis A. Sierra, et al.
出版: (2023-07-01)

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study
由: Stefan Klöppel, et al.
出版: (2015-10-01)

Sociokarma and Kindred Spirits: An Acknowledgement
由: Susanne Kerekes
出版: (2023-12-01)

A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p.
由: Consortium, I
出版: (2001)

A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11.
由: Ogdie, M, et al.
出版: (2003)

The molecular pathogenesis of migraine: new developments and opportunities.
由: Zameel Cader, M
出版: (2013)

LINKAGE STUDIES IN A KINDRED WITH HYPOCALCIURIC HYPERCALCEMIA AND INCREASING SERUM PARATHYROID-HORMONE LEVELS INDICATE GENETIC-HETEROGENEITY
由: Trump, D, et al.
出版: (1993)

Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits
由: Teumer, A, et al.
出版: (2016)

Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study
由: Govinda R. Poudel, et al.
出版: (2015-02-01)

Tetrabenazine as anti-chorea therapy in Huntington Disease: an open-label continuation study. Huntington Study Group/TETRA-HD Investigators
由: Frank Samuel
出版: (2009-12-01)

Significant linkage to migrane with aura on chromosome 11q24
由: Cader, Z, et al.
出版: (2003)

Significant linkage to migraine with aura on chromosome 11q24.
由: Cader, Z, et al.
出版: (2003)

The tides : and kindred phenomena in the solar system/
由: 187515 Darwin, George Howard
出版: (1962)

Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice.
由: Bice, P, et al.
出版: (2009)

Huntington's Disease: Can Mice Lead the Way to Treatment?
由: Crook, Zachary Ryan, et al.
出版: (2014)

Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.
由: Sanaz Gabery, et al.
出版: (2015-01-01)