Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis.
The creatine kinase (CK) system is involved in the rapid transport of high-energy phosphates from the mitochondria to the sites of maximal energy requirements such as myofibrils and sarcolemmal ion pumps. Hearts of mice with a combined knockout of cytosolic M-CK and mitochondrial CK (M/Mito-CK(-/-))...
المؤلفون الرئيسيون: | Spindler, M, Meyer, K, Strömer, H, Leupold, A, Boehm, E, Wagner, H, Neubauer, S |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2004
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مواد مشابهة
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Altered calcium homeostasis and increased susceptibility to ischemia in creatine kinase-deficient hearts
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