Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
The hypoxia inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an α/β-heterodimeric transcription factor that regulates the expression of hundreds of genes in a tissue context dependent manner. The major hypoxia-sensing component of the HIF system involves ox...
Main Authors: | Chan, M, Ilott, N, Schödel, J, Sims, D, Tumber, A, Lippl, K, Mole, D, Pugh, C, Ratcliffe, P, Ponting, C, Schofield, C |
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Format: | Journal article |
Language: | English |
Published: |
American Society for Biochemistry and Molecular Biology
2016
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