Adult thymic medullary epithelium is maintained and regenerated by linage-restricted cells rather than bipotent progenitors
Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-map...
| Main Authors: | , , , , , , , |
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| 格式: | Journal article |
| 出版: |
Cell Press
2015
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