Adult thymic medullary epithelium is maintained and regenerated by linage-restricted cells rather than bipotent progenitors

Adult thymic medullary epithelium is maintained and regenerated by linage-restricted cells rather than bipotent progenitors

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Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-map...

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Bibliographic Details
Main Authors:	Ohigashi, I, Zuklys, S, Sakata, M, Mayer, C, Hamazaki, Y, Minato, N, Hollander, G, Takahama, Y
Format:	Journal article
Published:	Cell Press 2015

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