Dopamine reveals neural circuit mechanisms of fly memory.
A goal of memory research is to understand how changing the weight of specific synapses in neural circuits in the brain leads to an appropriate learned behavioral response. Finding the relevant synapses should allow investigators to probe the underlying physiological and molecular operations that en...
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797090394507313152 |
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| author | Waddell, S |
| author_facet | Waddell, S |
| author_sort | Waddell, S |
| collection | OXFORD |
| description | A goal of memory research is to understand how changing the weight of specific synapses in neural circuits in the brain leads to an appropriate learned behavioral response. Finding the relevant synapses should allow investigators to probe the underlying physiological and molecular operations that encode memories and permit their retrieval. In this review I discuss recent work in Drosophila that implicates specific subsets of dopaminergic (DA) neurons in aversive reinforcement and appetitive motivation. The zonal architecture of these DA neurons is likely to reveal the functional organization of aversive and appetitive memory in the mushroom bodies. Combinations of fly DA neurons might code negative and positive value, consistent with a motivational systems role as proposed in mammals. |
| first_indexed | 2024-03-07T03:17:59Z |
| format | Journal article |
| id | oxford-uuid:b672e50f-cc64-4652-b181-499f2786d13a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:17:59Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:b672e50f-cc64-4652-b181-499f2786d13a2022-03-27T04:41:09ZDopamine reveals neural circuit mechanisms of fly memory.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b672e50f-cc64-4652-b181-499f2786d13aEnglishSymplectic Elements at Oxford2010Waddell, SA goal of memory research is to understand how changing the weight of specific synapses in neural circuits in the brain leads to an appropriate learned behavioral response. Finding the relevant synapses should allow investigators to probe the underlying physiological and molecular operations that encode memories and permit their retrieval. In this review I discuss recent work in Drosophila that implicates specific subsets of dopaminergic (DA) neurons in aversive reinforcement and appetitive motivation. The zonal architecture of these DA neurons is likely to reveal the functional organization of aversive and appetitive memory in the mushroom bodies. Combinations of fly DA neurons might code negative and positive value, consistent with a motivational systems role as proposed in mammals. |
| spellingShingle | Waddell, S Dopamine reveals neural circuit mechanisms of fly memory. |
| title | Dopamine reveals neural circuit mechanisms of fly memory. |
| title_full | Dopamine reveals neural circuit mechanisms of fly memory. |
| title_fullStr | Dopamine reveals neural circuit mechanisms of fly memory. |
| title_full_unstemmed | Dopamine reveals neural circuit mechanisms of fly memory. |
| title_short | Dopamine reveals neural circuit mechanisms of fly memory. |
| title_sort | dopamine reveals neural circuit mechanisms of fly memory |
| work_keys_str_mv | AT waddells dopaminerevealsneuralcircuitmechanismsofflymemory |