Carbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds
The synthesis of the first branched sugar amino acid (SAA) scaffolds [methyl (3R,4R,5R)-5-azidomethyl-3,4-dihydroxy-tetrahydrofuran-3-carboxylate and methyl (3R,4R,5S)-5-azidomethyl-3,4-dihydroxy-tetrahydrofuran-3-carboxylate] by an efficient intramolecular displacement of a highly hindered neopenty...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797090404706811904 |
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| author | Simone, M Edwards, A Tranter, G Fleet, G |
| author_facet | Simone, M Edwards, A Tranter, G Fleet, G |
| author_sort | Simone, M |
| collection | OXFORD |
| description | The synthesis of the first branched sugar amino acid (SAA) scaffolds [methyl (3R,4R,5R)-5-azidomethyl-3,4-dihydroxy-tetrahydrofuran-3-carboxylate and methyl (3R,4R,5S)-5-azidomethyl-3,4-dihydroxy-tetrahydrofuran-3-carboxylate] by an efficient intramolecular displacement of a highly hindered neopentyl triflate allows access to enantiopure THF derivatives which have carbon substituents. © 2008 Elsevier Ltd. All rights reserved. |
| first_indexed | 2024-03-07T03:18:07Z |
| format | Journal article |
| id | oxford-uuid:b681bf9b-b468-45b2-a911-a6a5bae0e3c9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:18:07Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:b681bf9b-b468-45b2-a911-a6a5bae0e3c92022-03-27T04:41:24ZCarbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffoldsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b681bf9b-b468-45b2-a911-a6a5bae0e3c9EnglishSymplectic Elements at Oxford2008Simone, MEdwards, ATranter, GFleet, GThe synthesis of the first branched sugar amino acid (SAA) scaffolds [methyl (3R,4R,5R)-5-azidomethyl-3,4-dihydroxy-tetrahydrofuran-3-carboxylate and methyl (3R,4R,5S)-5-azidomethyl-3,4-dihydroxy-tetrahydrofuran-3-carboxylate] by an efficient intramolecular displacement of a highly hindered neopentyl triflate allows access to enantiopure THF derivatives which have carbon substituents. © 2008 Elsevier Ltd. All rights reserved. |
| spellingShingle | Simone, M Edwards, A Tranter, G Fleet, G Carbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds |
| title | Carbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds |
| title_full | Carbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds |
| title_fullStr | Carbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds |
| title_full_unstemmed | Carbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds |
| title_short | Carbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds |
| title_sort | carbon branched delta tetrahydrofuran sugar amino acids saas as dipeptide isostere scaffolds |
| work_keys_str_mv | AT simonem carbonbrancheddeltatetrahydrofuransugaraminoacidssaasasdipeptideisosterescaffolds AT edwardsa carbonbrancheddeltatetrahydrofuransugaraminoacidssaasasdipeptideisosterescaffolds AT tranterg carbonbrancheddeltatetrahydrofuransugaraminoacidssaasasdipeptideisosterescaffolds AT fleetg carbonbrancheddeltatetrahydrofuransugaraminoacidssaasasdipeptideisosterescaffolds |