Stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones.
Zinc or a chromium(II) source with 3-(bromomethyl)furan-2(5H)-one (3) and an aldehyde gives β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones 5 in good yields and high diastereoselectivities. The methodology is demonstrated in concise syntheses of (±)-hydroxymatairesinol (8) and (±)-methyleno...
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| Príomhchruthaitheoirí: |
Hodgson, D,
Talbot, E,
Clark, B |
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| Formáid: | Journal article
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| Teanga: | English |
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| Foilsithe / Cruthaithe: |
2011
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