Stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones.
Zinc or a chromium(II) source with 3-(bromomethyl)furan-2(5H)-one (3) and an aldehyde gives β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones 5 in good yields and high diastereoselectivities. The methodology is demonstrated in concise syntheses of (±)-hydroxymatairesinol (8) and (±)-methyleno...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Hauptverfasser: |
Hodgson, D,
Talbot, E,
Clark, B |
|---|
| Format: | Journal article
|
|---|
| Sprache: | English |
|---|
| Veröffentlicht: |
2011
|
|---|