Preservation of a critical epitope core region is associated with the high degree of flaviviral cross-reactivity exhibited by a dengue-specific CD4+ T cell clone.

Dengue is a member of the Flaviviridae, a large group of related viruses some of which co-circulate in certain regions (e.g. dengue and Yellow fever in South America). Immune responses cross-reactive between different dengue serotypes are important in the pathogenesis of dengue disease but it is not...

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Main Authors: Moran, E, Simmons, C, Vinh Chau, N, Luhn, K, Wills, B, Dung, N, Thao, L, Hien, T, Farrar, J, Rowland-Jones, S, Dong, T
格式: Journal article
语言:English
出版: 2008