Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package

A description of the materials and methods is included within the TEP datasheet. SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity....

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолч:	Brennan, P
Бусад зохиолчид:	Cox, O
Формат:	Dataset
Хэвлэсэн:	University of Oxford 2018
Нөхцлүүд:	Drug Discovery Structural Genomics Chemical Biology

Ижил төстэй зүйлс

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
-н: Cox, O
Хэвлэсэн: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
-н: Cox, O
Хэвлэсэн: (2018)

LIM domain kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
-н: Mathea, S
Хэвлэсэн: (2018)

LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
-н: Bullock, A
Хэвлэсэн: (2018)

LIM Domain Kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
-н: Mathea, S
Хэвлэсэн: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
-н: Brennan, P
Хэвлэсэн: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
-н: Brennan, P
Хэвлэсэн: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
-н: Brennan, P
Хэвлэсэн: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
-н: Brennan, P
Хэвлэсэн: (2018)

Cyclin-dependent kinase 12 (CDK12), human kinase domain; a Target Enabling Package
-н: Dixon-Clarke, S
Хэвлэсэн: (2018)

Cyclin-Dependent Kinase 12 (CDK12), human kinase domain; A Target Enabling Package
Хэвлэсэн: (2018)

Cyclin-Dependent Kinase 12 (CDK12), Human Kinase Domain; A Target Enabling Package
Хэвлэсэн: (2018)

Human RECQL5 Helicase; A Target Enabling Package
-н: Gileadi, O
Хэвлэсэн: (2018)

Human RECQL5 Helicase; A Target Enabling Package
-н: Newman, J
Хэвлэсэн: (2018)

Human RECQL5 Helicase; A Target Enabling Package
-н: Newman, J
Хэвлэсэн: (2018)

With No Lysine Kinase 3 (WNK3); A Target Enabling Package
-н: Bullock, A
Хэвлэсэн: (2018)

With no lysine kinase 3 (WNK3); A Target Enabling Package
-н: Pinkas, D
Хэвлэсэн: (2018)

With No Lysine Kinase 3 (WNK3); A Target Enabling Package
-н: Pinkas, D
Хэвлэсэн: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
Хэвлэсэн: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
-н: Kopec, J
Хэвлэсэн: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
-н: Yue, W
Хэвлэсэн: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
-н: Savitsky, P
Хэвлэсэн: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
-н: Savitsky, P
Хэвлэсэн: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
-н: Carpenter, E
Хэвлэсэн: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
-н: Chu, A
Хэвлэсэн: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
-н: Dong, Y
Хэвлэсэн: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
-н: Newman, J
Хэвлэсэн: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
-н: Gileadi, O
Хэвлэсэн: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
-н: Newman, J
Хэвлэсэн: (2018)

Solution structure of a pleckstrin-homology domain
-н: Hajduk, Philip J., зэрэг
Хэвлэсэн: (2012)

Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily
-н: Marc Lenoir, зэрэг
Хэвлэсэн: (2015-10-01)

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
-н: Harlan, John E., зэрэг
Хэвлэсэн: (2012)

Structural characterization of the interaction between a Pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate
-н: Harlan, John E., зэрэг
Хэвлэсэн: (2012)

Analysis of multiple compound–protein interactions reveals novel bioactive molecules
-н: Hiroaki Yabuuchi, зэрэг
Хэвлэсэн: (2011-03-01)

Structural and functional characterization of the kindlin-1 pleckstrin homology domain.
-н: Yates, L, зэрэг
Хэвлэсэн: (2012)

Structure and lipid binding properties of the kindlin-3 pleckstrin homology domain
-н: Ni, T, зэрэг
Хэвлэсэн: (2016)

Modes of interaction of pleckstrin homology domains with membranes: towards a computational biochemistry of membrane recognition
-н: Naughton, F, зэрэг
Хэвлэсэн: (2017)

Interactions of the pleckstrin homology domain with phosphatidylinositol phosphate and membranes: characterization via molecular dynamics simulations.
-н: Psachoulia, E, зэрэг
Хэвлэсэн: (2008)

Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.
-н: Lumb, C, зэрэг
Хэвлэсэн: (2011)

Interactions of pleckstrin homology domains with membranes: adding back the bilayer via high throughput molecular dynamics
-н: Yamamoto, E, зэрэг
Хэвлэсэн: (2016)