Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?

Xehetasun bibliografikoak
Egile Nagusiak:	Stewart, P, Tomlinson, J
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2009

Antzeko izenburuak

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
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Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
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The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
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The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
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Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
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A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
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11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome
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11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
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11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
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Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
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11 beta-hydroxysteroid dehydrogenase type 1 in obese children
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Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
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Cortisol Metabolism and Hepatic Expression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Patients with Non Alcoholic Fatty Liver Disease.
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Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
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Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
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The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
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Effects of glucocorticoids on fat mass and the therapeutic potential of targeting II beta-hydroxysteroid dehydrogenase type I in obesity
nork: Tomlinson, J
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Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
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11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
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Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
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Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
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Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
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11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
nork: Tomlinson, J, et al.
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Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
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Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
nork: Tomlinson, J, et al.
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11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.
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Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1: A novel pharmacological target in the metabolic syndrome
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Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.
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Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.
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Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.
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11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
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Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.
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Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
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Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice
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Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
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Selective inhibition of human type 1 11beta-hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics.
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11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
nork: Morgan, SA, et al.
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11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
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Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
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Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.
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