Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?

Bibliografske podrobnosti
Main Authors:	Stewart, P, Tomlinson, J
Format:	Journal article
Jezik:	English
Izdano:	2009

Podobne knjige/članki

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
od: Tomlinson, J, et al.
Izdano: (2001)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
od: Stewart, P, et al.
Izdano: (2002)

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
od: Tomlinson, J, et al.
Izdano: (2002)

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
od: Tomlinson, J, et al.
Izdano: (2000)

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
od: Tomlinson, J, et al.
Izdano: (2005)

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
od: Bujalska, I, et al.
Izdano: (2008)

11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome
od: Tomlinson, J, et al.
Izdano: (2005)

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
od: Morgan, SA, et al.
Izdano: (2010)

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
od: Tomlinson, J
Izdano: (2005)

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
od: Sinclair, A, et al.
Izdano: (2007)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
od: Wiegand, S, et al.
Izdano: (2007)

Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
od: Oppermann, U
Izdano: (2006)

Cortisol Metabolism and Hepatic Expression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Patients with Non Alcoholic Fatty Liver Disease.
od: Ahmed, A, et al.
Izdano: (2010)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
od: Wiegand, S, et al.
Izdano: (2007)

Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
od: Rauz, S, et al.
Izdano: (2004)

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
od: Tomlinson, J, et al.
Izdano: (2010)

Effects of glucocorticoids on fat mass and the therapeutic potential of targeting II beta-hydroxysteroid dehydrogenase type I in obesity
od: Tomlinson, J
Izdano: (2009)

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
od: Tomlinson, J, et al.
Izdano: (2002)

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
od: Swali, A, et al.
Izdano: (2008)

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
od: Bujalska, I, et al.
Izdano: (2007)

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
od: Bujalska, I, et al.
Izdano: (2006)

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
od: Bujalska, I, et al.
Izdano: (2005)

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
od: Tomlinson, J, et al.
Izdano: (2004)

Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
od: Hult, M, et al.
Izdano: (2004)

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
od: Tomlinson, J, et al.
Izdano: (2004)

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.
od: Gathercole, L, et al.
Izdano: (2013)

Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1: A novel pharmacological target in the metabolic syndrome
od: Oppermann, U, et al.
Izdano: (2003)

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.
od: Tomlinson, J, et al.
Izdano: (2003)

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.
od: Stulnig, T, et al.
Izdano: (2002)

Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.
od: Lavery, G, et al.
Izdano: (2012)

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
od: Bujalska, I, et al.
Izdano: (2002)

Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.
od: Maser, E, et al.
Izdano: (1997)

Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
od: Hult, M, et al.
Izdano: (2006)

Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice
od: Li H, et al.
Izdano: (2021-05-01)

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
od: Tomlinson, J, et al.
Izdano: (2001)

Selective inhibition of human type 1 11beta-hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics.
od: Hult, M, et al.
Izdano: (1998)

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
od: Morgan, SA, et al.
Izdano: (2009)

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
od: Valsamakis, G, et al.
Izdano: (2004)

Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
od: Oppermann, U, et al.
Izdano: (1997)

Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.
od: Hult, M, et al.
Izdano: (2001)