Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.
Nondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag reactive T cells. However, this may not be the sole explanation for tolerance, as we show...
| Main Authors: | , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2000
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| _version_ | 1826292714023419904 |
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| author | Graca, L Honey, K Adams, E Cobbold, S Waldmann, H |
| author_facet | Graca, L Honey, K Adams, E Cobbold, S Waldmann, H |
| author_sort | Graca, L |
| collection | OXFORD |
| description | Nondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag reactive T cells. However, this may not be the sole explanation for tolerance, as we show in this study that tolerance is maintained through a dominant regulatory mechanism which, like tolerance induced with CD4 Abs, manifests as infectious tolerance. Therefore, tolerance induced with anti-CD154 Abs involves not only the deletion of potentially aggressive T cells, but also a contagious spread of tolerance to new cohorts of graft-reactive T cells as they arise. |
| first_indexed | 2024-03-07T03:18:57Z |
| format | Journal article |
| id | oxford-uuid:b6c687f6-a7b7-4079-a58e-8b9b5fef14a5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:18:57Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:b6c687f6-a7b7-4079-a58e-8b9b5fef14a52022-03-27T04:43:24ZCutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b6c687f6-a7b7-4079-a58e-8b9b5fef14a5EnglishSymplectic Elements at Oxford2000Graca, LHoney, KAdams, ECobbold, SWaldmann, HNondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag reactive T cells. However, this may not be the sole explanation for tolerance, as we show in this study that tolerance is maintained through a dominant regulatory mechanism which, like tolerance induced with CD4 Abs, manifests as infectious tolerance. Therefore, tolerance induced with anti-CD154 Abs involves not only the deletion of potentially aggressive T cells, but also a contagious spread of tolerance to new cohorts of graft-reactive T cells as they arise. |
| spellingShingle | Graca, L Honey, K Adams, E Cobbold, S Waldmann, H Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. |
| title | Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. |
| title_full | Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. |
| title_fullStr | Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. |
| title_full_unstemmed | Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. |
| title_short | Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. |
| title_sort | cutting edge anti cd154 therapeutic antibodies induce infectious transplantation tolerance |
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