Reactivation of a developmentally silenced embryonic globin gene

The α- and β-globin loci harbor developmentally expressed genes, which are silenced throughout post-natal life. Reactivation of these genes may offer therapeutic approaches for the hemoglobinopathies, the most common single gene disorders. Here, we address mechanisms regulating the embryonically exp...

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Main Authors:	King, AJ, Songdej, D, Downes, DJ, Beagrie, RA, Liu, S, Buckley, M, Hua, P, Suciu, MC, Marieke Oudelaar, A, Hanssen, LLP, Jeziorska, D, Roberts, N, Carpenter, SJ, Francis, H, Telenius, J, Olijnik, A-A, Sharpe, JA, Sloane-Stanley, J, Eglinton, J, Kassouf, MT, Orkin, SH, Pennacchio, LA, Davies, JOJ, Hughes, JR, Higgs, DR, Babbs, C
Format:	Journal article
Sprog:	English
Udgivet:	Springer Nature 2021

Reactivation of a developmentally silenced embryonic globin gene

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