Reactivation of a developmentally silenced embryonic globin gene

Reactivation of a developmentally silenced embryonic globin gene

The α- and β-globin loci harbor developmentally expressed genes, which are silenced throughout post-natal life. Reactivation of these genes may offer therapeutic approaches for the hemoglobinopathies, the most common single gene disorders. Here, we address mechanisms regulating the embryonically exp...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: King, AJ, Songdej, D, Downes, DJ, Beagrie, RA, Liu, S, Buckley, M, Hua, P, Suciu, MC, Marieke Oudelaar, A, Hanssen, LLP, Jeziorska, D, Roberts, N, Carpenter, SJ, Francis, H, Telenius, J, Olijnik, A-A, Sharpe, JA, Sloane-Stanley, J, Eglinton, J, Kassouf, MT, Orkin, SH, Pennacchio, LA, Davies, JOJ, Hughes, JR, Higgs, DR, Babbs, C
Format: Journal article
Sprache:English
Veröffentlicht: Springer Nature 2021

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