T cell responses to cytomegalovirus
Human cytomegalovirus (HCMV) establishes a latent infection that generally remains asymptomatic in immune-competent hosts for decades but can cause serious illness in immune-compromised individuals. The long-term control of CMV requires considerable effort from the host immune system and has a lasti...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Nature Publishing Group
2016
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| _version_ | 1826292729287540736 |
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| author | Klenerman, P Oxenius, A |
| author_facet | Klenerman, P Oxenius, A |
| author_sort | Klenerman, P |
| collection | OXFORD |
| description | Human cytomegalovirus (HCMV) establishes a latent infection that generally remains asymptomatic in immune-competent hosts for decades but can cause serious illness in immune-compromised individuals. The long-term control of CMV requires considerable effort from the host immune system and has a lasting impact on the profile of the immune system. One hallmark of CMV infection is the maintenance of large populations of CMV-specific memory CD8+ T cells — a phenomenon termed memory inflation — and emerging data suggest that memory inflation is associated with impaired immunity in the elderly. In this Review, we discuss the molecular triggers that promote memory inflation, the idea that memory inflation could be considered a natural pathway of T cell maturation that could be harnessed in vaccination, and the broader implications of CMV infection and the T cell responses it elicits. |
| first_indexed | 2024-03-07T03:19:11Z |
| format | Journal article |
| id | oxford-uuid:b6db1a5e-688d-4873-b3f1-bb7a565f627e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:19:11Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:b6db1a5e-688d-4873-b3f1-bb7a565f627e2022-03-27T04:44:05ZT cell responses to cytomegalovirusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b6db1a5e-688d-4873-b3f1-bb7a565f627eEnglishSymplectic Elements at OxfordNature Publishing Group2016Klenerman, POxenius, AHuman cytomegalovirus (HCMV) establishes a latent infection that generally remains asymptomatic in immune-competent hosts for decades but can cause serious illness in immune-compromised individuals. The long-term control of CMV requires considerable effort from the host immune system and has a lasting impact on the profile of the immune system. One hallmark of CMV infection is the maintenance of large populations of CMV-specific memory CD8+ T cells — a phenomenon termed memory inflation — and emerging data suggest that memory inflation is associated with impaired immunity in the elderly. In this Review, we discuss the molecular triggers that promote memory inflation, the idea that memory inflation could be considered a natural pathway of T cell maturation that could be harnessed in vaccination, and the broader implications of CMV infection and the T cell responses it elicits. |
| spellingShingle | Klenerman, P Oxenius, A T cell responses to cytomegalovirus |
| title | T cell responses to cytomegalovirus |
| title_full | T cell responses to cytomegalovirus |
| title_fullStr | T cell responses to cytomegalovirus |
| title_full_unstemmed | T cell responses to cytomegalovirus |
| title_short | T cell responses to cytomegalovirus |
| title_sort | t cell responses to cytomegalovirus |
| work_keys_str_mv | AT klenermanp tcellresponsestocytomegalovirus AT oxeniusa tcellresponsestocytomegalovirus |