POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN
The synthesis of two epimeric spirohydantoins of glucopyranose provides the first examples of pyranose analogues of hydantocidin: molecular modelling correctly predicted that one of the epimers would be a potent inhibitor of glycogen phosphorylase. This is the first example of specific enzyme inhibi...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
1995
|
| _version_ | 1826292734151884800 |
|---|---|
| author | Bichard, C Mitchell, E Wormald, M Watson, K Johnson, L Zographos, S Koutra, D Oikonomakos, N Fleet, G |
| author_facet | Bichard, C Mitchell, E Wormald, M Watson, K Johnson, L Zographos, S Koutra, D Oikonomakos, N Fleet, G |
| author_sort | Bichard, C |
| collection | OXFORD |
| description | The synthesis of two epimeric spirohydantoins of glucopyranose provides the first examples of pyranose analogues of hydantocidin: molecular modelling correctly predicted that one of the epimers would be a potent inhibitor of glycogen phosphorylase. This is the first example of specific enzyme inhibition by a spirohydantoin at the anomeric position of a sugar. © 1995. |
| first_indexed | 2024-03-07T03:19:16Z |
| format | Journal article |
| id | oxford-uuid:b6e1b1ea-e12e-44f6-835c-b3743208355e |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:19:16Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:b6e1b1ea-e12e-44f6-835c-b3743208355e2022-03-27T04:44:16ZPOTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDINJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b6e1b1ea-e12e-44f6-835c-b3743208355eSymplectic Elements at Oxford1995Bichard, CMitchell, EWormald, MWatson, KJohnson, LZographos, SKoutra, DOikonomakos, NFleet, GThe synthesis of two epimeric spirohydantoins of glucopyranose provides the first examples of pyranose analogues of hydantocidin: molecular modelling correctly predicted that one of the epimers would be a potent inhibitor of glycogen phosphorylase. This is the first example of specific enzyme inhibition by a spirohydantoin at the anomeric position of a sugar. © 1995. |
| spellingShingle | Bichard, C Mitchell, E Wormald, M Watson, K Johnson, L Zographos, S Koutra, D Oikonomakos, N Fleet, G POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN |
| title | POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN |
| title_full | POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN |
| title_fullStr | POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN |
| title_full_unstemmed | POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN |
| title_short | POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN |
| title_sort | potent inhibition of glycogen phosphorylase by a spirohydantoin of glucopyranose first pyranose analogs of hydantocidin |
| work_keys_str_mv | AT bichardc potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin AT mitchelle potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin AT wormaldm potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin AT watsonk potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin AT johnsonl potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin AT zographoss potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin AT koutrad potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin AT oikonomakosn potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin AT fleetg potentinhibitionofglycogenphosphorylasebyaspirohydantoinofglucopyranosefirstpyranoseanalogsofhydantocidin |