Transcriptional regulatory functions of nuclear long noncoding RNAs.
Several nuclear localised intergenic long noncoding RNAs (lncRNAs) have been ascribed regulatory roles in transcriptional control and their number is growing rapidly. Initially, these transcripts were shown to function locally, near their sites of synthesis, by regulating the expression of neighbour...
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| Fformat: | Journal article |
| Iaith: | English |
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Cell Press
2014
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| _version_ | 1826292751496380416 |
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| author | Vance, K Ponting, C |
| author_facet | Vance, K Ponting, C |
| author_sort | Vance, K |
| collection | OXFORD |
| description | Several nuclear localised intergenic long noncoding RNAs (lncRNAs) have been ascribed regulatory roles in transcriptional control and their number is growing rapidly. Initially, these transcripts were shown to function locally, near their sites of synthesis, by regulating the expression of neighbouring genes. More recently, lncRNAs have been demonstrated to interact with chromatin at several thousand different locations across multiple chromosomes and to modulate large-scale gene expression programs. Although the molecular mechanisms involved in targeting lncRNAs to distal binding sites remain poorly understood, the spatial organisation of the genome may have a role in specifying lncRNA function. Recent advances indicate that intergenic lncRNAs may exert more widespread effects on gene regulation than previously anticipated. |
| first_indexed | 2024-03-07T03:19:32Z |
| format | Journal article |
| id | oxford-uuid:b6f576aa-8f68-4be1-b3b9-d613206f8648 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:19:32Z |
| publishDate | 2014 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:b6f576aa-8f68-4be1-b3b9-d613206f86482022-03-27T04:44:54ZTranscriptional regulatory functions of nuclear long noncoding RNAs.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b6f576aa-8f68-4be1-b3b9-d613206f8648EnglishSymplectic Elements at OxfordCell Press2014Vance, KPonting, CSeveral nuclear localised intergenic long noncoding RNAs (lncRNAs) have been ascribed regulatory roles in transcriptional control and their number is growing rapidly. Initially, these transcripts were shown to function locally, near their sites of synthesis, by regulating the expression of neighbouring genes. More recently, lncRNAs have been demonstrated to interact with chromatin at several thousand different locations across multiple chromosomes and to modulate large-scale gene expression programs. Although the molecular mechanisms involved in targeting lncRNAs to distal binding sites remain poorly understood, the spatial organisation of the genome may have a role in specifying lncRNA function. Recent advances indicate that intergenic lncRNAs may exert more widespread effects on gene regulation than previously anticipated. |
| spellingShingle | Vance, K Ponting, C Transcriptional regulatory functions of nuclear long noncoding RNAs. |
| title | Transcriptional regulatory functions of nuclear long noncoding RNAs. |
| title_full | Transcriptional regulatory functions of nuclear long noncoding RNAs. |
| title_fullStr | Transcriptional regulatory functions of nuclear long noncoding RNAs. |
| title_full_unstemmed | Transcriptional regulatory functions of nuclear long noncoding RNAs. |
| title_short | Transcriptional regulatory functions of nuclear long noncoding RNAs. |
| title_sort | transcriptional regulatory functions of nuclear long noncoding rnas |
| work_keys_str_mv | AT vancek transcriptionalregulatoryfunctionsofnuclearlongnoncodingrnas AT pontingc transcriptionalregulatoryfunctionsofnuclearlongnoncodingrnas |