201 Regulation of INOS Function, Redox State and NRF2 Activation by Macrophage GCH1 and Tetrahydrobiopterin.
: Tetrahydrobiopterin (BH4) is an essential co-factor for NO production from NOS enzymes. When BH4 levels become limiting these enzymes can become 'un-coupled', leading to superoxide production. GTP cyclohydrolase I (GTPCH), encoded by GCH1, is an essential enzyme in the biosynthesis of BH...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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