Acute graft-versus-host disease without costimulation via CD28.
T lymphocyte activity is enhanced by costimulatory signals mediated through CD28 binding to B7-1/B7-2 on antigen-presenting cells. Several recent studies have shown that graft-versus-host disease (GVHD) can be inhibited by in vivo treatment with CTLA4Ig, which blocks CD28-B7 interactions. These find...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1826292799612387328 |
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| author | Speiser, D Bachmann, M Shahinian, A Mak, T Ohashi, P |
| author_facet | Speiser, D Bachmann, M Shahinian, A Mak, T Ohashi, P |
| author_sort | Speiser, D |
| collection | OXFORD |
| description | T lymphocyte activity is enhanced by costimulatory signals mediated through CD28 binding to B7-1/B7-2 on antigen-presenting cells. Several recent studies have shown that graft-versus-host disease (GVHD) can be inhibited by in vivo treatment with CTLA4Ig, which blocks CD28-B7 interactions. These findings prompted us to investigate the role of CD28 in acute GVHD, using gene-targeted mice. We performed the experiments in the context of strong allogeneic MHC stimulation (H2(b) anti-H2(d)) and weak stimulation (H2(d) anti-H2(b)). In both directions, efficient in vitro T-cell cytotoxicity and acute lethal GVHD were induced by CD28-deficient lymphocytes, which was only partially delayed when compared with wild-type mice. We conclude that lethal GVHD can develop without costimulation via CD28. |
| first_indexed | 2024-03-07T03:20:16Z |
| format | Journal article |
| id | oxford-uuid:b72e0a3d-d691-4440-b880-b62aada55214 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:20:16Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:b72e0a3d-d691-4440-b880-b62aada552142022-03-27T04:46:42ZAcute graft-versus-host disease without costimulation via CD28.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b72e0a3d-d691-4440-b880-b62aada55214EnglishSymplectic Elements at Oxford1997Speiser, DBachmann, MShahinian, AMak, TOhashi, PT lymphocyte activity is enhanced by costimulatory signals mediated through CD28 binding to B7-1/B7-2 on antigen-presenting cells. Several recent studies have shown that graft-versus-host disease (GVHD) can be inhibited by in vivo treatment with CTLA4Ig, which blocks CD28-B7 interactions. These findings prompted us to investigate the role of CD28 in acute GVHD, using gene-targeted mice. We performed the experiments in the context of strong allogeneic MHC stimulation (H2(b) anti-H2(d)) and weak stimulation (H2(d) anti-H2(b)). In both directions, efficient in vitro T-cell cytotoxicity and acute lethal GVHD were induced by CD28-deficient lymphocytes, which was only partially delayed when compared with wild-type mice. We conclude that lethal GVHD can develop without costimulation via CD28. |
| spellingShingle | Speiser, D Bachmann, M Shahinian, A Mak, T Ohashi, P Acute graft-versus-host disease without costimulation via CD28. |
| title | Acute graft-versus-host disease without costimulation via CD28. |
| title_full | Acute graft-versus-host disease without costimulation via CD28. |
| title_fullStr | Acute graft-versus-host disease without costimulation via CD28. |
| title_full_unstemmed | Acute graft-versus-host disease without costimulation via CD28. |
| title_short | Acute graft-versus-host disease without costimulation via CD28. |
| title_sort | acute graft versus host disease without costimulation via cd28 |
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