Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing

Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing

<p>In eukaryotes, recombination plays a critical role in both the production of viable gametes and as a population genetic process. Here, we are interested in studying recombination as it provides insight into a process that has shaped variation. To this end, we study the evolution of cross-ov...

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Bibliografiske detaljer
Hovedforfatter:	Venn, O
Andre forfattere:	McVean, G
Format:	Thesis
Sprog:	English
Udgivet:	2013
Fag:	Mathematical genetics and bioinformatics (statistics) Medical Sciences

Lignende værker

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Bayesian methods for fine mapping in genetic association studies
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Bayesian and frequentist methods and analyses of genome-wide association studies
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LD-based SNP and genotype calling from next-generation sequencing reads.
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The estimation of recombination rates from population genetic data
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Udgivet: (2007)

Probabilistic models of RNA secondary structure
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The detection, structure and uses of extended haplotype identity in population genetic data
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Application of the Neutral Indel Model to genome sequences for diverse metazoans
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Quantifying the underestimation of relative risks from genome-wide association studies
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Udgivet: (2011)

Large-scale genetic analysis of quantitative traits
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Design and analysis of genome-wide association studies
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Accessing complex genomic variation in Plasmodium falciparum natural infections
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Udgivet: (2015)

Comparative analysis of derived mutations across human populations.
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Udgivet: (2013)

Statistical methods for mapping complex traits
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Udgivet: (2014)

Statistical methods for the analysis of genetic association studies
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Statistical methods for genotype microarray data on large cohorts of individuals
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Evolution of highly fecund organisms
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Gene x gene interactions in genome wide association studies
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An integrated genomic approach for the identification and analysis of single nucleotide polymorphisms that affect cancer in humans
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NucleoFinder: a statistical approach for the detection of nucleosome positions
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A method for the identification of biological pathways
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On genetic variants underlying common disease
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Using phylogeny to improve genome-wide distant homology recognition
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Extensions of the case-control design in genome-wide association studies
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Statistical models for single-cell data
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HLA*IMP - an integrated framework for imputing classical HLA alleles from SNP genotypes
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Advances in statistical bioinformatics : models and integrative inference for high-throughput data /
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Importance sampling on the coalescent with recombination
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Multilocus sequence analysis of the pathogen Neisseria meningitidis
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Udgivet: (2005)

Genetic and genomic analysis of Arabidopsis thaliana with low-coverage next-generation sequencing data
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A statistical approach using network structure in the prediction of protein characteristics
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Biobank-scale ancestral recombination graphs: inference and applications to the analysis of complex traits
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Udgivet: (2022)

Medical relevance and functional consequences of protein truncating variants
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Multiple sequence analysis in the presence of alignment uncertainty
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Statistical analysis of natural selection in RNA virus populations
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Simultaneous estimation of population size changes and splits times using importance sampling
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Patterns of symptoms in major depressive disorder and genetics of the disorder using low-pass sequencing data
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